GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9346353 | 1 | rs59738216 | chr6:70492176 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.41 | 0.000704 | Sleep duration |
| THCA | cis | rs2129782 | 1 | rs59745808 | chr8:89452576 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs59374417 | 1 | rs59762006 | chr3:119280625 | ADPRH | chr3:119298523-119308791:+ | -0.22 | -3.59 | 0.000366 | Vitiligo |
| THCA | cis | rs12216499 | 1 | rs59770215 | chr6:159371062 | RSPH3 | chr6:159398268-159421198:- | 0.28 | 6 | 3.97E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs6011674 | 1 | rs59784306 | chr20:61859596 | BIRC7 | chr20:61867276-61871853:+ | 0.32 | 3.88 | 0.00012 | Response to cytadine analogues (cytosine arabinoside) |
| THCA | cis | rs6011674 | 1 | rs59784306 | chr20:61859596 | NKAIN4 | chr20:61872137-61885892:- | 0.31 | 3.37 | 0.000819 | Response to cytadine analogues (cytosine arabinoside) |
| THCA | cis | rs11825709 | 1 | rs59793398 | chr11:93717927 | HEPHL1 | chr11:93754378-93847374:+ | 0.43 | 3.48 | 0.000553 | Obesity-related traits |
| THCA | cis | rs2243480 | 1 | rs59794892 | chr7:65415873 | CCT6P1 | chr7:65216092-65228661:+ | 0.38 | 6.08 | 2.41E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs59794892 | chr7:65415873 | CRCP | chr7:65579805-65619551:+ | -0.27 | -4.13 | 4.33E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs59794892 | chr7:65415873 | RABGEF1 | chr7:66093890-66276446:+ | 0.54 | 6.85 | 2.3E-11 | Diabetic kidney disease |
| THCA | cis | rs6832769 | 1 | rs59804446 | chr4:56429541 | TMEM165 | chr4:56262090-56292342:+ | 0.14 | 3.51 | 0.000497 | Personality dimensions |
| THCA | cis | rs7737355 | 1 | rs59808242 | chr5:130754894 | P4HA2 | chr5:131528306-131563556:- | -0.25 | -4.92 | 1.21E-6 | Life satisfaction |
| THCA | cis | rs12435908 | 1 | rs59822422 | chr14:65889566 | LOC645431 | chr14:65877313-65879335:- | -0.6 | -7.88 | 2.31E-14 | Ischemic stroke |
| THCA | cis | rs6988636 | 1 | rs59834873 | chr8:124188824 | FAM83A | chr8:124191287-124222317:+ | -0.33 | -4.38 | 1.46E-5 | Urinary uromodulin levels |
| THCA | cis | rs3820928 | 1 | rs59904960 | chr2:227761269 | COL4A4 | chr2:227867435-228029275:- | 0.16 | 3.97 | 8.32E-5 | Pulmonary function |